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4 Comments:

Anonymous said...

the info here was very helpfull cause we know a few more things about the swine flu thank you

3:04 AM

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Anonymous said...

i live here in california there has been swine flu case it went from 7 to 14 now and they are saying not to panic every store here are out hand sanitizer and theres no more sanitizer until two week later but people could be dead by then how come the goverment is not doing more to prtevent the outbreak

2:43 PM

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Anonymous said...

You asked if there was any testing in your podcast. This report was posted in 2005 in a medical journal. You will not find information on news sites.



Jürgen 2005: Solórzano Alicia; Webby Richard J; Lager Kelly M; Janke Bruce H; García-Sastre Adolfo; Richt A

Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs.

Journal of virology 2005;79(12):7535-43.



It has been shown previously that the nonstructural protein NS1 of influenza virus is an alpha/beta interferon (IFN-alpha/beta) antagonist, both in vitro and in experimental animal model systems. However, evidence of this function in a natural host has not yet been obtained. Here we investigated the role of the NS1 protein in the virulence of a swine influenza virus (SIV) isolate in pigs by using reverse genetics. The virulent wild-type A/Swine/Texas/4199-2/98 (TX/98) virus and various mutants encoding carboxy-truncated NS1 proteins were rescued. Growth properties of TX/98 viruses with mutated NS1, induction of IFN in tissue culture, and virulence-attenuation in pigs were analyzed and compared to those of the recombinant wild-type TX/98 virus. Our results indicate that deletions in the NS1 protein decrease the ability of the TX/98 virus to prevent IFN-alpha/beta synthesis in pig cells. Moreover, all NS1 mutant viruses were attenuated in pigs, and this correlated with the amount of IFN-alpha/beta induced in vitro. These data suggest that the NS1 protein of SIV is a virulence factor. Due to their attenuation, NS1-mutated swine influenza viruses might have a great potential as live attenuated vaccine candidates against SIV infections of pigs.

12:09 AM

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2:26 AM

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